Printed in the U.S.A. CYCLOSPORINE AUGMENTS REACTIVITY OF ISOLATED BLOOD VESSELS
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چکیده
Administration of cyclosporine (CS) as an immunosuppressive agent in clinical tr a:s plan tation is associated with multiple side effects including nephrotoxicity ald hypertension. These two effect~ could be related in that the renal changes may be secondary to alterations in organ blood flow. The present studies investigate the ability of CS to augment contractile responsiveness in blood vessels from normotensive rats. Isometric force generation was measured in isolated tail arteries and portal
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